Structural highlights
Function
[RCRO_BP434] Cro represses genes normally expressed in early phage development and is necessary for the late stage of lytic growth. It does this by binding to the OL and OR operators regions normally used by the repressor protein for lysogenic maintenance.
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
The crystal structure of phage 434 Cro protein has been determined and refined against 2.35 A data to an R-factor of 19.5%. The protein comprises five alpha-helices and shows the helix-turn-helix motif found in other repressor proteins.
Structure of phage 434 Cro protein at 2.35 A resolution.,Mondragon A, Wolberger C, Harrison SC J Mol Biol. 1989 Jan 5;205(1):179-88. PMID:2647998[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Mondragon A, Wolberger C, Harrison SC. Structure of phage 434 Cro protein at 2.35 A resolution. J Mol Biol. 1989 Jan 5;205(1):179-88. PMID:2647998
