Structural highlights
Function
[APBA3_HUMAN] May modulate processing of the beta-amyloid precursor protein (APP) and hence formation of beta-APP. May enhance the activity of HIF1A in macrophages by inhibiting the activity of HIF1AN.[1]
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
References
- ↑ Sakamoto T, Seiki M. Mint3 enhances the activity of hypoxia-inducible factor-1 (HIF-1) in macrophages by suppressing the activity of factor inhibiting HIF-1. J Biol Chem. 2009 Oct 30;284(44):30350-9. doi: 10.1074/jbc.M109.019216. Epub 2009, Sep 2. PMID:19726677 doi:http://dx.doi.org/10.1074/jbc.M109.019216
