Talk:SARS-CoV-2 Papain-Like protease (PLpro)

From Proteopedia

Introduction

Papain-like protease (PLpro) from SARS-CoV-2 is a 315 amino acids long cysteine protease is found in the large multi-domain membrane-bound non-structural protein 3 (nsp3)(1945 residues) between the SARS domain (SUD/HVR) and a nucleic acid-binding domain (NAD) (Frick et al, 2020, OSIPIUK et al., 2021). It has a high percentage of cysteine residues (3.5%) (OSIPIUK et al., 2021).

SARS-CoV-2 polyprotein

The first SARS-CoV-2 open reading frame (ORF) codes for one large polyprotein, 1ab (7096 aminoacids) or 1a (4405 amino acids) built by fifteen non-coding proteins including the two proteases responsible to cleave the polyprotein: Main protease (Mpro or 3Cl-pro) and Papain-Like protease (OSIPIUK et al., 2021).