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1db1
From Proteopedia
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CRYSTAL STRUCTURE OF THE NUCLEAR RECEPTOR FOR VITAMIN D COMPLEXED TO VITAMIN D
Contents |
Overview
The action of 1 alpha, 25-dihydroxyvitamin D3 is mediated by its nuclear, receptor (VDR), a ligand-dependent transcription regulator. We report the, 1.8 A resolution crystal structure of the complex between a VDR, ligand-binding domain (LBD) construct lacking the highly variable, VDR-specific insertion domain and vitamin D. The construct exhibits the, same binding affinity for vitamin D and transactivation ability as the, wild-type protein, showing that the N-terminal part of the LBD is, essential for its structural and functional integrity while the large, insertion peptide is dispensable. The structure reveals the active, conformation of the bound ligand and allows understanding of the different, binding properties of some synthetic analogs.
Disease
Known diseases associated with this structure: Osteoporosis, involutional, 166710 (1) OMIM:[601769], Rickets, vitamin D-resistant, type IIA OMIM:[601769]
About this Structure
1DB1 is a Single protein structure of sequence from Homo sapiens with VDX as ligand. Full crystallographic information is available from OCA.
Reference
The crystal structure of the nuclear receptor for vitamin D bound to its natural ligand., Rochel N, Wurtz JM, Mitschler A, Klaholz B, Moras D, Mol Cell. 2000 Jan;5(1):173-9. PMID:10678179
Page seeded by OCA on Mon Nov 12 16:30:40 2007
Categories: Homo sapiens | Single protein | Klaholz, B. | Mitschler, A. | Moras, D. | Rochel, N. | Wurtz, J.M. | VDX | Complex
