1dgn
From Proteopedia
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SOLUTION STRUCTURE OF ICEBERG, AN INHIBITOR OF INTERLEUKIN-1BETA GENERATION
Overview
ProIL-1beta is a proinflammatory cytokine that is proteolytically, processed to its active form by caspase-1. Upon receipt of a, proinflammatory stimulus, an upstream adaptor, RIP2, binds and, oligomerizes caspase-1 zymogen, promoting its autoactivation. ICEBERG is a, novel protein that inhibits generation of IL-1beta by interacting with, caspase-1 and preventing its association with RIP2. ICEBERG is induced by, proinflammatory stimuli, suggesting that it may be part of a negative, feedback loop. Consistent with this, enforced retroviral expression of, ICEBERG inhibits lipopolysaccharide-induced IL-1beta generation. The, structure of ICEBERG reveals it to be a member of the death-domain-fold, superfamily. The distribution of surface charge is complementary to the, homologous prodomain of caspase-1, suggesting that charge-charge, interactions mediate binding of ICEBERG to the prodomain of caspase-1.
About this Structure
1DGN is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
ICEBERG: a novel inhibitor of interleukin-1beta generation., Humke EW, Shriver SK, Starovasnik MA, Fairbrother WJ, Dixit VM, Cell. 2000 Sep 29;103(1):99-111. PMID:11051551
Page seeded by OCA on Mon Nov 12 16:32:26 2007
