SARS-CoV-2 enzyme 3CL-PRO

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SARS-CoV-2 NSP6 Main protease 6lu7)

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Function

Proteinase 3CL-PRO Cleaves the C-terminus of replicase polyprotein at 11 sites. Recognizes substrates containing the core sequence [ILMVF]-Q-|-[SGACN]. Also able to bind an ADP-ribose-1"-phosphate (ADRP).[1][2]

Disease

Relevance

Structural highlights

See also

Coronavirus_Disease 2019 (COVID-19)

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References

  1. ↑ Modeling of the SARS-COV-2 Genome
  2. ↑ Zhang C, Zheng W, Huang X, Bell EW, Zhou X, Zhang Y. Protein Structure and Sequence Reanalysis of 2019-nCoV Genome Refutes Snakes as Its Intermediate Host and the Unique Similarity between Its Spike Protein Insertions and HIV-1. J Proteome Res. 2020 Apr 3;19(4):1351-1360. doi: 10.1021/acs.jproteome.0c00129., Epub 2020 Mar 24. PMID:32200634 doi:http://dx.doi.org/10.1021/acs.jproteome.0c00129

Proteopedia Page Contributors and Editors (what is this?)

Joel L. Sussman, Jaime Prilusky

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