2j58

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spinqualitylabelsall models 2j58, resolution 2.25Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

THE STRUCTURE OF WZA

Overview

Many types of bacteria produce extracellular polysaccharides (EPSs). Some, are secreted polymers and show only limited association with the cell, surface, whereas others are firmly attached to the cell surface and form a, discrete structural layer, the capsule, which envelopes the cell and, allows the bacteria to evade or counteract the host immune system. EPSs, have critical roles in bacterial colonization of surfaces, such as, epithelia and medical implants; in addition some EPSs have important, industrial and biomedical applications in their own right. Here we, describe the 2.26 A resolution structure of the 340 kDa octamer of Wza, an, integral outer membrane lipoprotein, which is essential for group 1, capsule export in Escherichia coli. The transmembrane region is a novel, ... [(full description)]

About this Structure

2J58 is a [Single protein] structure of sequence from [Escherichia coli] with SO4, OCT and HEX as [ligands]. Full crystallographic information is available from [OCA].

Reference

Wza the translocon for E. coli capsular polysaccharides defines a new class of membrane protein., Dong C, Beis K, Nesper J, Brunkan-Lamontagne AL, Clarke BR, Whitfield C, Naismith JH, Nature. 2006 Nov 9;444(7116):226-9. Epub 2006 Nov 1. PMID:17086202

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