1x5a

Structural highlights

Function

[EPHA1_MOUSE] Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC. Plays also a role in angiogenesis and regulates cell proliferation. May play a role in apoptosis.^[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

• Ephrin receptor 3D structures

References

1. ↑ Duffy SL, Coulthard MG, Spanevello MD, Herath NI, Yeadon TM, McCarron JK, Carter JC, Tonks ID, Kay GF, Phillips GE, Boyd AW. Generation and characterization of EphA1 receptor tyrosine kinase reporter knockout mice. Genesis. 2008 Oct;46(10):553-61. doi: 10.1002/dvg.20434. PMID:18802966 doi:http://dx.doi.org/10.1002/dvg.20434