1dzi

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Image:1dzi.gif

1dzi, resolution 2.1Å

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INTEGRIN ALPHA2 I DOMAIN / COLLAGEN COMPLEX

Contents

Overview

We have determined the crystal structure of a complex between the I domain, of integrin alpha2beta1 and a triple helical collagen peptide containing a, critical GFOGER motif. Three loops on the upper surface of the I domain, that coordinate a metal ion also engage the collagen, with a collagen, glutamate completing the coordination sphere of the metal. Comparison with, the unliganded I domain reveals a change in metal coordination linked to a, reorganization of the upper surface that together create a complementary, surface for binding collagen. Conformational changes propagate from the, upper surface to the opposite pole of the domain, suggesting both a basis, for affinity regulation and a pathway for signal transduction. The, structural features observed here may represent a general mechanism for, integrin-ligand recognition.

Disease

Known diseases associated with this structure: Glycoprotein Ia deficiency (1) OMIM:[192974], Neonatal alloimmune thrombocytopenia OMIM:[192974]

About this Structure

1DZI is a Protein complex structure of sequences from Homo sapiens with CO and NH2 as ligands. Full crystallographic information is available from OCA.

Reference

Structural basis of collagen recognition by integrin alpha2beta1., Emsley J, Knight CG, Farndale RW, Barnes MJ, Liddington RC, Cell. 2000 Mar 31;101(1):47-56. PMID:10778855

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