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Structure

Overall Structure

Inactive State

Intermediate Form

PAM Bound Form

Figure 3:This is PAM located in its binding pocket. PAM, JNJ-40411813, is shown in magenta and colored by atom. The image shows four labelled alpha helices (III, V, VI, and VII) that create the binding pocket in the 7TM region of mGlu2 for PAM to bind within. The binding of PAM promotes the function of the mGLu2.

NAM Bound Form

Active State

Function

Clinical Relevance

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