Structural highlights
Publication Abstract from PubMed
What a pentaplexing situation: Isoguanine (iG) is an isomer of guanine, where the positions of the C2 amino group and the C6 carboxy group are swapped. iG can self-assemble into pentads in the presence of alkali metal cations. Cs(+) ions were found to stabilize a pentaplex of d(T(iG)(4) T). Solution NMR studies of this pentaplex in the presence of Cs(+) ions (or Na(+) , K(+) , Rb(+) , or NH(4) (+) cations) demonstrate its stability and structure.
Solution Structure of a Parallel-Stranded Oligoisoguanine DNA Pentaplex Formed by d(T(iG)(4) T) in the Presence of Cs(+) Ions.,Kang M, Heuberger B, Chaput JC, Switzer C, Feigon J Angew Chem Int Ed Engl. 2012 Jul 5. doi: 10.1002/anie.201203459. PMID:22767484[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Kang M, Heuberger B, Chaput JC, Switzer C, Feigon J. Solution Structure of a Parallel-Stranded Oligoisoguanine DNA Pentaplex Formed by d(T(iG)(4) T) in the Presence of Cs(+) Ions. Angew Chem Int Ed Engl. 2012 Jul 5. doi: 10.1002/anie.201203459. PMID:22767484 doi:10.1002/anie.201203459
