Sandbox Reserved 1701

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This Sandbox is Reserved from February 28 through September 1, 2022 for use in the course CH462 Biochemistry II taught by R. Jeremy Johnson at the Butler University, Indianapolis, USA. This reservation includes Sandbox Reserved 1700 through Sandbox Reserved 1729.

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MRGPRX2 Human Itch G-Protein Coupled Receptor (GPCR)

Human Itch GPCR Structure. Transmembrane protein shown in red, alpha subunit in blue, beta subunit in magenta, and gamma subunit in yellow.

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1 Background
- 1.1 Ligands
- 1.2 Significance
2 Structure
- 2.1 Heterotrimeric G-Protein Structure
- 2.2 Novel Characteristics
3 Function
4 3D Structures
5 References

Background

Ligands

Significance

Structure

Heterotrimeric G-Protein Structure

Novel Characteristics

Toggle Switch

PIF/LLF Motif

DRY/ ERC Motif

MRGPRX2 has an rather than a DRY Motif.

ERC Motif

Sodium Site

The MRGPRX2 consists of Asp-75 and Gly-116 compared to the [https://proteopedia.org/wiki/index.php/Neurotensin_receptor#sodium binding pocket

previously conserved] Asp-120 and Ser-162.

Disulfide Bonds

Further Information

Function

Before Activation

After Activation

Clinical Relevance

3D Structures

References

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