User:Nhi Pham/Sandbox 1

From Proteopedia

Human Oligosaccharyltransferase complex A (OST-A)

References

1. ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
2. ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
3. ↑ doi: https://dx.doi.org/10.1038/nature25755/ref>.Inhumans,N-linkedglycosylationiscatalyzedco-translationallybyanenzymecomplexcalledoligosaccharyltransferasecomplexA(OST-A)intheroughER.ThismeansthatthepeptidechainisglycosylatedbythiscomplexasitissynthesizedbytheribosomeandenterstheERlumenthroughtransloconproteinSec61(Luet.al.,2018).Assuggestedbythename,thisenzymecomplextransfersthehighmannosefourteen-sugarchainfromalipid-linkedoligosaccharidedonorcontainingdolicholpyrophosphatetothepeptidechaincontainingtheAsn-X-Thr(N-X-T)sequence,whereXisanyaminoacidbutnotProline(Baiet.al.,2019).Inaddition,thisenzymecomplexisalsopartoftheglycosyltransferase-C(GT-C)fold,whichisaproteinthathasatransmembranehelicaldomainandamixofα/βsolubledomains(BaiandLi2019).Onthispage,thestructureoftheOST-Aanditscomponents;itsmechanism,anddiseasesassociatedwiththiscomplexarediscussed.==Structure====ActiveSite====Function====Disease==ThisisasamplescenecreatedwithSATto<scenename="/12/3456/Sample/1">color</scene>byGroup,andanothertomake<scenename="/12/3456/Sample/2">atransparentrepresentation</scene>oftheprotein.YoucanmakeyourownscenesonSATstartingfromscratchorloadingandeditingoneofthesesamplescenes.