1h5n

From Proteopedia

proteopedia linkproteopedia link

spinqualitylabelsall models 1h5n, resolution 2.0Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

DMSO REDUCTASE MODIFIED BY THE PRESENCE OF DMS AND AIR

Overview

The bis-molybdopterin enzyme dimethylsulfoxide reductase (DMSOR) from, Rhodobacter capsulatus catalyzes the conversion of dimethyl sulfoxide, (DMSO) to dimethyl sulfide (DMS), reversibly, in the presence of suitable, e(-)-donors or e(-)-acceptors. The catalytically significant intermediate, formed by reaction of DMSOR with DMS ('the DMS species') and a damaged, enzyme form derived by reaction of the latter with O(2) (DMS-modified, enzyme, DMSOR(mod)D) have been investigated. Evidence is presented that Mo, in the DMS species is not, as widely assumed, Mo(IV). Formation of the DMS, species is reversed on removing DMS or by addition of an excess of DMSO., Equilibrium constants for the competing reactions of DMS and DMSO with the, oxidized enzyme (K(d) = 0.07 +/- 0.01 and 21 +/- 5 mM, ... [(full description)]

About this Structure

1H5N is a [Single protein] structure of sequence from [Rhodobacter capsulatus] with SO4, PGD and 6MO as [ligands]. Full crystallographic information is available from [OCA].

Reference

Reactions of dimethylsulfoxide reductase in the presence of dimethyl sulfide and the structure of the dimethyl sulfide-modified enzyme., Bray RC, Adams B, Smith AT, Richards RL, Lowe DJ, Bailey S, Biochemistry. 2001 Aug 21;40(33):9810-20. PMID:11502174

Page seeded by OCA on Mon Oct 29 18:06:45 2007