Structural highlights
Function
[LACB_BOVIN] Primary component of whey, it binds retinol and is probably involved in the transport of that molecule.
Publication Abstract from PubMed
beta-lactoglobulin is the major component of whey. Here, the adduct formed upon the reaction of the protein with oxaliplatin (OXA) has been prepared, structurally characterized by X-ray crystallography and electrospray ionization-mass spectrometry, and evaluated as a cytotoxic agent. The data demonstrate that OXA rapidly binds beta-lactoglobulin via coordination with a Met7 side chain upon release of the oxalate ligand. The adduct is significantly more cytotoxic than the free drug and induces apoptosis in cancer cells. Overall, our results suggest that metallodrug/beta-lactoglobulin adducts can be used as anticancer agents and that the protein can be used as a metallodrug delivery system.
Protein-Based Delivery Systems for Anticancer Metallodrugs: Structure and Biological Activity of the Oxaliplatin/beta-Lactoglobulin Adduct.,Monti DM, Loreto D, Iacobucci I, Ferraro G, Pratesi A, D'Elia L, Monti M, Merlino A Pharmaceuticals (Basel). 2022 Mar 30;15(4). pii: ph15040425. doi:, 10.3390/ph15040425. PMID:35455422[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Monti DM, Loreto D, Iacobucci I, Ferraro G, Pratesi A, D'Elia L, Monti M, Merlino A. Protein-Based Delivery Systems for Anticancer Metallodrugs: Structure and Biological Activity of the Oxaliplatin/beta-Lactoglobulin Adduct. Pharmaceuticals (Basel). 2022 Mar 30;15(4). pii: ph15040425. doi:, 10.3390/ph15040425. PMID:35455422 doi:http://dx.doi.org/10.3390/ph15040425
