3let

Structural highlights

Function

[VOPS_VIBPA] Adenylyltransferase involved in virulence by mediating the addition of adenosine 5'-monophosphate (AMP) to specific threonine residue of host Rho GTPases RhoA, Rac and Cdc42. The resulting AMPylation prevents the interaction of Rho GTPases with downstream effectors, thereby inhibiting actin assembly in infected cells.^{[1] [2]}

References

1. ↑ Yarbrough ML, Li Y, Kinch LN, Grishin NV, Ball HL, Orth K. AMPylation of Rho GTPases by Vibrio VopS disrupts effector binding and downstream signaling. Science. 2009 Jan 9;323(5911):269-72. Epub 2008 Nov 27. PMID:19039103 doi:http://dx.doi.org/1166382
2. ↑ Luong P, Kinch LN, Brautigam CA, Grishin NV, Tomchick DR, Orth K. Kinetic and structural insights into the mechanism of AMPylation by VopS Fic domain. J Biol Chem. 2010 Jun 25;285(26):20155-63. doi: 10.1074/jbc.M110.114884. Epub, 2010 Apr 21. PMID:20410310 doi:http://dx.doi.org/10.1074/jbc.M110.114884