1h4l

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spinqualitylabelsall models PDB ID 1h4l Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
1h4l, resolution 2.65Å ()
Related:	1lfr
Structural annotation: Resources: CATH : 1H4La02, 1H4La01, 1H4Lb01, 1H4Lb02, 1H4Ld00, 1H4Le00 InterPro : Ipr008271, Ipr011009, Ipr000719, Ipr002290, Ipr013763, Ipr004944, Ipr011028 Pfam : PF00069, PF03261 SCOP : d1h4la_, d1h4lb_, d1h4ld_, d1h4le_ UniProt : Q00535, Q15078
Functional annotation: Cellular component: nucleus dendrite growth cone cell soma neuromuscular junction lamellipodium cell projection membrane cytosol axon cytoplasm filopodium dendritic spine cyclin-dependent protein kinase 5 activator complex contractile fiber Biological process: neuron differentiation cell migration embryonic development axonogenesis neurite development cell division cell proliferation protein amino acid phosphorylation regulation of cell migration positive regulation of neuron apoptosis cell cycle cell-matrix adhesion neuron migration ionotropic glutamate receptor signaling pathway brain development neuron adhesion regulation of cyclin-dependent protein kinase activity axon guidance regulation of neuron differentiation axonal fasciculation acetylcholine receptor signaling, muscarinic pathway Molecular function: ErbB-3 class receptor binding cyclin-dependent protein kinase activity ATP binding nucleotide binding transferase activity protein binding ErbB-2 class receptor binding protein kinase activity acetylcholine receptor activator activity kinase activity tau-protein kinase activity protein serine/threonine kinase activity cadherin binding calcium ion binding cyclin-dependent protein kinase 5 activator activity protein serine/threonine kinase activator activity
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, PDBsum, RCSB
Coordinates:	save as pdb, mmCIF, xml

STRUCTURE AND REGULATION OF THE CDK5-P25(NCK5A) COMPLEX

Overview

CDK5 plays an indispensable role in the central nervous system, and its deregulation is involved in neurodegeneration. We report the crystal structure of a complex between CDK5 and p25, a fragment of the p35 activator. Despite its partial structural similarity with the cyclins, p25 displays an unprecedented mechanism for the regulation of a cyclin-dependent kinase. p25 tethers the unphosphorylated T loop of CDK5 in the active conformation. Residue Ser159, equivalent to Thr160 on CDK2, contributes to the specificity of the CDK5-p35 interaction. Its substitution with threonine prevents p35 binding, while the presence of alanine affects neither binding nor kinase activity. Finally, we provide evidence that the CDK5-p25 complex employs a distinct mechanism from the phospho-CDK2-cyclin A complex to establish substrate specificity.

About this Structure

1H4L is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure and regulation of the CDK5-p25(nck5a) complex., Tarricone C, Dhavan R, Peng J, Areces LB, Tsai LH, Musacchio A, Mol Cell. 2001 Sep;8(3):657-69. PMID:11583627 Page seeded by OCA on Fri May 2 18:25:26 2008