3q5w

Structural highlights

Function

[CUT8_SCHPO] Involved in ubiquitin-mediated protein degradation. Regulatory factor in the ubiquitin/proteasome pathway that controls the turnover of proteasome substrates. Targets proteasomes to the nucleus and facilitates the degradation of nuclear proteins like mitotic cyclin and cut2. Required for normal progression of anaphase.^{[1] [2] [3]}

References

1. ↑ Tatebe H, Yanagida M. Cut8, essential for anaphase, controls localization of 26S proteasome, facilitating destruction of cyclin and Cut2. Curr Biol. 2000 Nov 2;10(21):1329-38. PMID:11084332
2. ↑ Takeda K, Yanagida M. Regulation of nuclear proteasome by Rhp6/Ubc2 through ubiquitination and destruction of the sensor and anchor Cut8. Cell. 2005 Aug 12;122(3):393-405. PMID:16096059 doi:http://dx.doi.org/S0092-8674(05)00502-7
3. ↑ Samejima I, Yanagida M. Identification of cut8+ and cek1+, a novel protein kinase gene, which complement a fission yeast mutation that blocks anaphase. Mol Cell Biol. 1994 Sep;14(9):6361-71. PMID:8065367