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3r0i

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IspC in complex with an N-methyl-substituted hydroxamic acid

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PDB ID 3r0i

Show:Asymmetric Unit Biological Assembly

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Structural highlights

3r0i is a 2 chain structure with sequence from Ecoli. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	,
Related:	1k5h, 1onp, 1q0l
Gene:	dxr, ispC, yaeM, b0173, JW0168 (ECOLI)
Activity:	1-deoxy-D-xylulose-5-phosphate reductoisomerase, with EC number 1.1.1.267
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[DXR_ECOLI] Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).[HAMAP-Rule:MF_00183]

Publication Abstract from PubMed

Reverse hydroxamate-based inhibitors of IspC, a key enzyme of the non-mevalonate pathway of isoprenoid biosynthesis and a potential antimalarial target, were synthesized and biologically evaluated. The binding mode of one derivative in complex with EcIspC and a divalent metal ion was clarified by X-ray analysis. Pilot experiments have demonstrated in vivo potential.

Reverse Fosmidomycin Derivatives against the Antimalarial Drug Target IspC (Dxr).,Behrendt CT, Kunfermann A, Illarionova V, Matheeussen A, Pein MK, Grawert T, Kaiser J, Bacher A, Eisenreich W, Illarionov B, Fischer M, Maes L, Groll M, Kurz T J Med Chem. 2011 Aug 25. PMID:21866890^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Behrendt CT, Kunfermann A, Illarionova V, Matheeussen A, Pein MK, Grawert T, Kaiser J, Bacher A, Eisenreich W, Illarionov B, Fischer M, Maes L, Groll M, Kurz T. Reverse Fosmidomycin Derivatives against the Antimalarial Drug Target IspC (Dxr). J Med Chem. 2011 Aug 25. PMID:21866890 doi:10.1021/jm200694q

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 See Also
5 References

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3r0i

From Proteopedia

IspC in complex with an N-methyl-substituted hydroxamic acid

Structural highlights

Function

Publication Abstract from PubMed

See Also

References

Contents

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