Function
Chorismate mutase.(CHM) is a key enzyme in the biosynthesis of aromatic amino acids Phe and Tyr . CHM catalyzes the rearrangement of chorismate to prephenate which is the precursor of Phe and Tyr[1].. CHM is divided ןמto 2 classes: AroH class which is monofunctional and thק bifunctional AroQ.
Disease
Relevance
Structural highlights
The 3D structure of the complex of CHM with transition state analog shows the CHM structure containing a dimer of pseudosymmetry but only the N-terminal half contains an available active site pocket. The transition state analog is buried in the active site pocket and forms extensive H-bond network with CHM. Arg 49 and Arg 134 which are part of this network are conserved in all the known CHMs[2].
