Structural highlights
Publication Abstract from PubMed
It has been confirmed by our previous studies that a 2',4'-BNA(NC)[N-Me]-modified antisense gapmer displays high affinity and selectivity to the target RNA strand, promising mRNA inhibitory activity and excellent nuclease resistance. Herein, we have obtained a crystal structure that provides insights into these excellent antisense properties.
The crystal structure of a 2',4'-BNA(NC)[N-Me]-modified antisense gapmer in complex with the target RNA.,Kondo J, Nomura Y, Kitahara Y, Obika S, Torigoe H Chem Commun (Camb). 2016 Feb 7;52(11):2354-7. doi: 10.1039/c5cc08300a. PMID:26731288[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Kondo J, Nomura Y, Kitahara Y, Obika S, Torigoe H. The crystal structure of a 2',4'-BNA(NC)[N-Me]-modified antisense gapmer in complex with the target RNA. Chem Commun (Camb). 2016 Feb 7;52(11):2354-7. doi: 10.1039/c5cc08300a. PMID:26731288 doi:http://dx.doi.org/10.1039/c5cc08300a
