Gasdermin (GSDM) is the substrate of the inflamamatory Caspase downstream from inflamasomes which activate caspase. Inflammasomes are supramolecular signaling assemblies activating the lytic process against exogenous pathogens. GSDM is required for cytokine release and pyroptosis [1]. Pyropptosis is the regulated lytic cell death mediated by GSMD pore formation. GSDM D contains 2 domains: the N-terminal fragment which is pore-forming and the repressive C-terminal. The GSDM family contains 6 members in human.
Function
Disease
Relevance
Structural highlights
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