1fmk

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spinqualitylabelsall models 1fmk, resolution 1.5Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

CRYSTAL STRUCTURE OF HUMAN TYROSINE-PROTEIN KINASE C-SRC

Contents 1 Overview 2 Disease 3 About this Structure 4 Reference

Overview

The structure of a large fragment of the c-Src tyrosine kinase, comprising, the regulatory and kinase domains and the carboxy-terminal tall, has been, determined at 1.7 A resolution in a closed, inactive state. Interactions, among domains, stabilized by binding of the phosphorylated tail to the SH2, domain, lock the molecule in a conformation that simultaneously disrupts, the kinase active site and sequesters the binding surfaces of the SH2 and, SH3 domains. The structure shows how appropriate cellular signals, or, transforming mutations in v-Src, could break these interactions to produce, an open, active kinase.

Disease

Known disease associated with this structure: Colon cancer, advanced OMIM:[190090]

About this Structure

1FMK is a Single protein structure of sequence from Homo sapiens. Active as Transferase, with EC number and 2.7.10.2 2.7.10.1 and 2.7.10.2 Full crystallographic information is available from OCA.

Reference

Three-dimensional structure of the tyrosine kinase c-Src., Xu W, Harrison SC, Eck MJ, Nature. 1997 Feb 13;385(6617):595-602. PMID:9024657

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