Function
Dihydroorotase (DHO) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate in the pyrimidine biosynthesis pathway[1].
Relevance
The difference between bacterial and mammalian DHO makes it a promising drug target[2].
Structural highlights
The 3D structure of the complex of DHO with dihydroorotate and carbamoyl aspartate shows dihydroorotate bound to the protein subunit A active site via electrostatic interactions. The substrate carbamoyl aspartate binds to the active site of subunit B via 2 Thr residues[3].
3D structures of dihydroorotase
Dihydroorotase 3D structures
