Structural highlights
Publication Abstract from PubMed
The O2-binding carboxylate-bridged diiron site in DcrH-Hr was engineered in an effort to perform the H2O2-dependent oxidation of external substrates. A His residue was introduced near the diiron site in place of a conserved residue, Ile119. The I119H variant promotes the oxidation of guaiacol and 1,4-cyclohexadiene upon addition of H2O2.
HO-dependent substrate oxidation by an engineered diiron site in a bacterial hemerythrin.,Okamoto Y, Onoda A, Sugimoto H, Takano Y, Hirota S, Kurtz DM, Shiro Y, Hayashi T Chem Commun (Camb). 2014 Jan 8. PMID:24400317[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Okamoto Y, Onoda A, Sugimoto H, Takano Y, Hirota S, Kurtz DM, Shiro Y, Hayashi T. HO-dependent substrate oxidation by an engineered diiron site in a bacterial hemerythrin. Chem Commun (Camb). 2014 Jan 8. PMID:24400317 doi:http://dx.doi.org/10.1039/c3cc48108e
