1g3j
From Proteopedia
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CRYSTAL STRUCTURE OF THE XTCF3-CBD/BETA-CATENIN ARMADILLO REPEAT COMPLEX
Contents |
Overview
The Wnt signaling pathway plays critical roles in embryonic development, and tumorigenesis. Stimulation of the Wnt pathway results in the, accumulation of a nuclear beta-catenin/Tcf complex, activating Wnt target, genes. A crystal structure of beta-catenin bound to the beta-catenin, binding domain of Tcf3 (Tcf3-CBD) has been determined. The Tcf3-CBD forms, an elongated structure with three binding modules that runs antiparallel, to beta-catenin along the positively charged groove formed by the, armadillo repeats. Structure-based mutagenesis defines three sites in, beta-catenin that are critical for binding the Tcf3-CBD and are, differentially involved in binding APC, cadherin, and Axin. The structural, and mutagenesis data reveal a potential target for molecular drug design, studies.
Disease
Known diseases associated with this structure: Colorectal cancer OMIM:[116806], Hepatoblastoma OMIM:[116806], Hepatocellular carcinoma OMIM:[116806], Ovarian carcinoma, endometrioid type OMIM:[116806], Pilomatricoma OMIM:[116806]
About this Structure
1G3J is a Protein complex structure of sequences from Homo sapiens and Xenopus laevis. Full crystallographic information is available from OCA.
Reference
Crystal structure of a beta-catenin/Tcf complex., Graham TA, Weaver C, Mao F, Kimelman D, Xu W, Cell. 2000 Dec 8;103(6):885-96. PMID:11136974
Page seeded by OCA on Mon Nov 12 17:00:11 2007
