7ewm

Structural highlights

Function

[THP3_YEAST] Forms a complex with CSN12 that is recruited to transcribed genes and required for transcription elongation. May also be involved in pre-mRNA splicing.^{[1] [2] [3]}

References

1. ↑ Wilmes GM, Bergkessel M, Bandyopadhyay S, Shales M, Braberg H, Cagney G, Collins SR, Whitworth GB, Kress TL, Weissman JS, Ideker T, Guthrie C, Krogan NJ. A genetic interaction map of RNA-processing factors reveals links between Sem1/Dss1-containing complexes and mRNA export and splicing. Mol Cell. 2008 Dec 5;32(5):735-46. doi: 10.1016/j.molcel.2008.11.012. PMID:19061648 doi:http://dx.doi.org/10.1016/j.molcel.2008.11.012
2. ↑ Faza MB, Kemmler S, Jimeno S, Gonzalez-Aguilera C, Aguilera A, Hurt E, Panse VG. Sem1 is a functional component of the nuclear pore complex-associated messenger RNA export machinery. J Cell Biol. 2009 Mar 23;184(6):833-46. doi: 10.1083/jcb.200810059. Epub 2009 Mar, 16. PMID:19289793 doi:http://dx.doi.org/10.1083/jcb.200810059
3. ↑ Jimeno S, Tous C, Garcia-Rubio ML, Ranes M, Gonzalez-Aguilera C, Marin A, Aguilera A. New suppressors of THO mutations identify Thp3 (Ypr045c)-Csn12 as a protein complex involved in transcription elongation. Mol Cell Biol. 2011 Feb;31(4):674-85. doi: 10.1128/MCB.01188-10. Epub 2010 Dec, 13. PMID:21149575 doi:http://dx.doi.org/10.1128/MCB.01188-10