7vc4

Structural highlights

Function

[TOM7_HUMAN] Required for assembly and stability of the TOM complex. Positive regulator of PRKN translocation to damaged mitochondria. Acts probably by stabilizing PINK1 on the outer membrane of depolarized mitochondria.^{[1] [2]}

References

1. ↑ Kato H, Mihara K. Identification of Tom5 and Tom6 in the preprotein translocase complex of human mitochondrial outer membrane. Biochem Biophys Res Commun. 2008 May 9;369(3):958-63. doi:, 10.1016/j.bbrc.2008.02.150. Epub 2008 Mar 10. PMID:18331822 doi:http://dx.doi.org/10.1016/j.bbrc.2008.02.150
2. ↑ Hasson SA, Kane LA, Yamano K, Huang CH, Sliter DA, Buehler E, Wang C, Heman-Ackah SM, Hessa T, Guha R, Martin SE, Youle RJ. High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy. Nature. 2013 Dec 12;504(7479):291-5. doi: 10.1038/nature12748. Epub 2013 Nov 24. PMID:24270810 doi:http://dx.doi.org/10.1038/nature12748