Structural highlights
Function
[TPDB1_COMSP] Component of the terephthalate 1,2-dioxygenase multicomponent enzyme system which catalyzes the dioxygenation of terephthalate (TER/TPA) to 1,2-dihydroxy-3,5-cyclohexadiene-1,4-dicarboxylic acid (DCD). It can also use 2,5-dicarboxypyridine (PDC) and 1,4-napthalenedicarboxylic acid (NDC) as substrates, and preferentially uses NADPH which is the physiological electron donor.[1] [2] [3]
References
- ↑ Sasoh M, Masai E, Ishibashi S, Hara H, Kamimura N, Miyauchi K, Fukuda M. Characterization of the terephthalate degradation genes of Comamonas sp. strain E6. Appl Environ Microbiol. 2006 Mar;72(3):1825-32. PMID:16517628 doi:http://dx.doi.org/72/3/1825
- ↑ Fukuhara Y, Kasai D, Katayama Y, Fukuda M, Masai E. Enzymatic properties of terephthalate 1,2-dioxygenase of Comamonas sp. strain E6. Biosci Biotechnol Biochem. 2008 Sep;72(9):2335-41. doi: 10.1271/bbb.80236. Epub, 2008 Sep 7. PMID:18776687 doi:http://dx.doi.org/10.1271/bbb.80236
- ↑ Schlafli HR, Weiss MA, Leisinger T, Cook AM. Terephthalate 1,2-dioxygenase system from Comamonas testosteroni T-2: purification and some properties of the oxygenase component. J Bacteriol. 1994 Nov;176(21):6644-52. doi: 10.1128/jb.176.21.6644-6652.1994. PMID:7961417 doi:http://dx.doi.org/10.1128/jb.176.21.6644-6652.1994
