1gen

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spinqualitylabelsall models 1gen, resolution 2.15Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

C-TERMINAL DOMAIN OF GELATINASE A

Contents 1 Overview 2 Disease 3 About this Structure 4 Reference

Overview

The crystal structure of the haemopexin-like C-terminal domain of, gelatinase A reveals that it is a four-bladed beta-propeller protein. The, four blades are arranged around a channel-like opening in which Ca2+ and a, Na-Cl+ ion pair are bound.

Disease

Known diseases associated with this structure: Osteolysis, idiopathic, Saudi type OMIM:[120360], Winchester syndrome OMIM:[120360]

About this Structure

1GEN is a Single protein structure of sequence from Homo sapiens with ZN, CA, CL and NA as ligands. Active as Gelatinase A, with EC number 3.4.24.24 Full crystallographic information is available from OCA.

Reference

Crystal structure of the haemopexin-like C-terminal domain of gelatinase A., Libson AM, Gittis AG, Collier IE, Marmer BL, Goldberg GI, Lattman EE, Nat Struct Biol. 1995 Nov;2(11):938-42. PMID:7583664

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