4c1y

Structural highlights

Function

[LECF_ASPFU] Multispecific lectin that is able to recognize L-fucose in all possible linkages (PubMed:23695231, PubMed:27058347, PubMed:24340081, PubMed:25760594). These could be found not only in decomposed plant matter in soil, which is the natural environment for A.fumigatus, but also in various epitopes on human tissues (PubMed:25760594). Mediates binding of A.fumigatus conidia to airway mucinin a fucose dependent manner (PubMed:27058347). Stimulates IL-8 production by human bronchial cells in a dose-dependent manner, contributing to the inflammatory response observed upon the exposure of a patient to A.fumigatus, and thus might be an important virulence factor involved in an early stage of A.fumigatus infection (PubMed:24340081).^{[1] [2] [3] [4]}

References

1. ↑ Kuboi S, Ishimaru T, Tamada S, Bernard EM, Perlin DS, Armstrong D. Molecular characterization of AfuFleA, an L-fucose-specific lectin from Aspergillus fumigatus. J Infect Chemother. 2013 Dec;19(6):1021-8. doi: 10.1007/s10156-013-0614-9. Epub, 2013 May 22. PMID:23695231 doi:http://dx.doi.org/10.1007/s10156-013-0614-9
2. ↑ Houser J, Komarek J, Kostlanova N, Cioci G, Varrot A, Kerr SC, Lahmann M, Balloy V, Fahy JV, Chignard M, Imberty A, Wimmerova M. A Soluble Fucose-Specific Lectin from Aspergillus fumigatus Conidia - Structure, Specificity and Possible Role in Fungal Pathogenicity. PLoS One. 2013 Dec 10;8(12):e83077. doi: 10.1371/journal.pone.0083077. PMID:24340081 doi:http://dx.doi.org/10.1371/journal.pone.0083077
3. ↑ Houser J, Komarek J, Cioci G, Varrot A, Imberty A, Wimmerova M. Structural insights into Aspergillus fumigatus lectin specificity: AFL binding sites are functionally non-equivalent. Acta Crystallogr D Biol Crystallogr. 2015 Mar 1;71(Pt 3):442-53. doi:, 10.1107/S1399004714026595. Epub 2015 Feb 26. PMID:25760594 doi:http://dx.doi.org/10.1107/S1399004714026595
4. ↑ Kerr SC, Fischer GJ, Sinha M, McCabe O, Palmer JM, Choera T, Lim FY, Wimmerova M, Carrington SD, Yuan S, Lowell CA, Oscarson S, Keller NP, Fahy JV. FleA Expression in Aspergillus fumigatus Is Recognized by Fucosylated Structures on Mucins and Macrophages to Prevent Lung Infection. PLoS Pathog. 2016 Apr 8;12(4):e1005555. doi: 10.1371/journal.ppat.1005555., eCollection 2016 Apr. PMID:27058347 doi:http://dx.doi.org/10.1371/journal.ppat.1005555