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Publication Abstract from PubMed

DNA/RNA duplexes containing metal-ion-mediated base pairs (metallo-base pairs) have potential applications in developing nucleic acid-based nanodevices and genetic code expansion. Many metallo-base pairs are formed within duplexes stabilized by Watson-Crick base pairs. Recently, the crystal structure of an Ag(I) -DNA nanowire with an uninterrupted one-dimensional silver array was determined. Here, we present a new DNA helical wire, the "Ag(I) -DNA rod", containing an uninterrupted array of 11 Ag(I) ions. The Ag(I) -DNA rod consisted of only C-Ag(I) -C, G-Ag(I) -G, G-Ag(I) -5-bromouracil ((Br) U), and (Br) U-Ag(I) -(Br) U metallo base pairs, with no Watson-Crick pairs. The Ag(I) -DNA rods were connected by non-canonical G-G pairs in crystals. Notably, data from our absorbance, circular dichroism, nuclear magnetic resonance, and mass spectrometry analyses suggested that the Ag(I) -DNA rods formed in solution, as well as within crystals.

A Novel Ag(I) -DNA Rod Comprising a One-Dimensional Array of 11 Silver Ions within a Double Helical Structure.,Atsugi T, Ono A, Tasaka M, Eguchi N, Fujiwara S, Kondo J Angew Chem Int Ed Engl. 2022 May 31:e202204798. doi: 10.1002/anie.202204798. PMID:35641885^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.