| Structural highlights
Disease
[GALA_HUMAN] The disease is caused by variants affecting the gene represented in this entry.
Function
[GALA_HUMAN] Endocrine hormone of the central and peripheral nervous systems that binds and activates the G protein-coupled receptors GALR1, GALR2, and GALR3. This small neuropeptide may regulate diverse physiologic functions including contraction of smooth muscle of the gastrointestinal and genitourinary tract, growth hormone and insulin release and adrenal secretion.[1] [2] [3]
References
- ↑ McKnight GL, Karlsen AE, Kowalyk S, Mathewes SL, Sheppard PO, O'Hara PJ, Taborsky GJ Jr. Sequence of human galanin and its inhibition of glucose-stimulated insulin secretion from RIN cells. Diabetes. 1992 Jan;41(1):82-7. PMID:1370155
- ↑ Schmidt WE, Kratzin H, Eckart K, Drevs D, Mundkowski G, Clemens A, Katsoulis S, Schafer H, Gallwitz B, Creutzfeldt W. Isolation and primary structure of pituitary human galanin, a 30-residue nonamidated neuropeptide. Proc Natl Acad Sci U S A. 1991 Dec 15;88(24):11435-9. doi:, 10.1073/pnas.88.24.11435. PMID:1722333 doi:http://dx.doi.org/10.1073/pnas.88.24.11435
- ↑ Guipponi M, Chentouf A, Webling KE, Freimann K, Crespel A, Nobile C, Lemke JR, Hansen J, Dorn T, Lesca G, Ryvlin P, Hirsch E, Rudolf G, Rosenberg DS, Weber Y, Becker F, Helbig I, Muhle H, Salzmann A, Chaouch M, Oubaiche ML, Ziglio S, Gehrig C, Santoni F, Pizzato M, Langel U, Antonarakis SE. Galanin pathogenic mutations in temporal lobe epilepsy. Hum Mol Genet. 2015 Jun 1;24(11):3082-91. doi: 10.1093/hmg/ddv060. Epub 2015 Feb , 17. PMID:25691535 doi:http://dx.doi.org/10.1093/hmg/ddv060
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