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Template:STRUCTURE 1ick

LEFT-HANDED Z-DNA HEXAMER DUPLEX D(CGCGCG)2


Overview

The crystal structure of a left-handed Z-DNA hexamer duplex d(CGCGCG)(2) has been solved based on the anomalous diffraction signal of inherent P atoms using data collected at the single wavelength of 1.54 A. The anomalous signal of about 2% of the total diffracted intensity, constant for all nucleic acids, may be generally useful for solving crystal structures of DNA and RNA oligomers. The multiplicity of intensity measurements is shown to crucially affect the data quality and the ability to solve the phase problem. The anisotropic model refined to an R factor of 8.9% at 0.95 A resolution.

About this Structure

Full crystallographic information is available from OCA.

Reference

Anomalous signal of phosphorus used for phasing DNA oligomer: importance of data redundancy., Dauter Z, Adamiak DA, Acta Crystallogr D Biol Crystallogr. 2001 Jul;57(Pt 7):990-5. Epub 2001, Jun 21. PMID:11418767 Page seeded by OCA on Fri May 2 19:50:44 2008

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