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Publication Abstract from PubMed

Certain CD8 T cell responses are particularly effective at controlling infection, as exemplified by elite control of HIV in individuals harboring HLA-B57. To understand the structural features that contribute to CD8 T cell elite control, we focused on a strongly protective CD8 T cell response directed against a parasite-derived peptide (HF10) presented by an atypical MHC-I molecule, H-2Ld. This response exhibits a focused TCR repertoire dominated by Vbeta2, and a representative TCR (TG6) in complex with Ld-HF10 reveals an unusual structure in which both MHC and TCR contribute extensively to peptide specificity, along with a parallel footprint of TCR on its pMHC ligand. The parallel footprint is a common feature of Vbeta2-containing TCRs and correlates with an unusual Valpha-Vbeta interface, CDR loop conformations, and Vbeta2-specific germline contacts with peptides. Vbeta2 and Ld may represent "specialist" components for antigen recognition that allows for particularly strong and focused T cell responses.

Peptide Centric Vbeta Specific Germline Contacts Shape a Specialist T Cell Response.,Wang Y, Tsitsiklis A, Devoe S, Gao W, Chu HH, Zhang Y, Li W, Wong WK, Deane CM, Neau D, Slansky JE, Thomas PG, Robey EA, Dai S Front Immunol. 2022 Jul 29;13:847092. doi: 10.3389/fimmu.2022.847092. eCollection, 2022. PMID:35967379^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.