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7wwb

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Choline transporter-like protein 1

Structural highlights

7wwb is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

[CTL1_HUMAN] The disease is caused by variants affecting the gene represented in this entry.

Function

[CTL1_HUMAN] Choline transporter. Involved in membrane synthesis and myelin production.^[1] ^[2]

Publication Abstract from PubMed

The solute carrier (SLC) superfamily is the largest group of proteins responsible for the transmembrane transport of substances in human cells. It includes more than 400 members that are organized into 65 families according to their physiological function and sequence similarity. Different families of SLCs can adopt the same or different folds that determine the mechanism and reflect the evolutionary relationship between SLC members. Analysis of structural data in the literature before this work showed 13 different folds in the SLC superfamily covering 40 families and 343 members. To further study their mechanism, we systematically explored the SLC superfamily to look for more folds. Based on our results, at least three new folds are found for the SLC superfamily, one of which is in the choline-like transporter family (SLC44) and has been experimentally verified. Our work has laid a foundation and provided important insights for the systematic and comprehensive study of the structure and function of SLC.

Rational exploration of fold atlas for human solute carrier proteins.,Xie T, Chi X, Huang B, Ye F, Zhou Q, Huang J Structure. 2022 Jun 1. pii: S0969-2126(22)00189-7. doi:, 10.1016/j.str.2022.05.015. PMID:35700727^[3]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Michel V, Bakovic M. The solute carrier 44A1 is a mitochondrial protein and mediates choline transport. FASEB J. 2009 Aug;23(8):2749-58. doi: 10.1096/fj.08-121491. Epub 2009 Apr 8. PMID:19357133 doi:http://dx.doi.org/10.1096/fj.08-121491
↑ Fagerberg CR, Taylor A, Distelmaier F, Schroder HD, Kibaek M, Wieczorek D, Tarnopolsky M, Brady L, Larsen MJ, Jamra RA, Seibt A, Hejbol EK, Gade E, Markovic L, Klee D, Nagy P, Rouse N, Agarwal P, Dolinsky VW, Bakovic M. Choline transporter-like 1 deficiency causes a new type of childhood-onset neurodegeneration. Brain. 2020 Jan 1;143(1):94-111. doi: 10.1093/brain/awz376. PMID:31855247 doi:http://dx.doi.org/10.1093/brain/awz376
↑ Xie T, Chi X, Huang B, Ye F, Zhou Q, Huang J. Rational exploration of fold atlas for human solute carrier proteins. Structure. 2022 Jun 1. pii: S0969-2126(22)00189-7. doi:, 10.1016/j.str.2022.05.015. PMID:35700727 doi:http://dx.doi.org/10.1016/j.str.2022.05.015