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1h6i

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Revision as of 15:06, 12 November 2007 by OCA (Talk | contribs)
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Image:1h6i.gif

1h6i, resolution 3.54Å

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A REFINED STRUCTURE OF HUMAN AQUAPORIN 1

Contents

Overview

A refined structure of the human water channel aquaporin-1 is presented., The model rests on the high resolution X-ray structure of the homologous, bacterial glycerol transporter GlpF, electron crystallographic data at 3.8, A resolution and a multiple sequence alignment of the aquaporin, superfamily. The crystallographic R and free R values (36.7% and 37.8%), for the refined structure are significantly lower than for previous, models. Improved geometry and enhanced stability in molecular dynamics, simulations demonstrate a significant improvement of the aquaporin-1, structure. Comparison with previous aquaporin-1 models shows significant, differences, not only in the loop regions, but also in the core of the, water channel.

Disease

Known diseases associated with this structure: Aquaporin-1 deficiency OMIM:[107776], Blood group, Colton OMIM:[107776]

About this Structure

1H6I is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

A refined structure of human aquaporin-1., de Groot BL, Engel A, Grubmuller H, FEBS Lett. 2001 Aug 31;504(3):206-11. PMID:11532455

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