Sandbox Reserved 1737

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This Sandbox is Reserved from August 30, 2022 through May 31, 2023 for use in the course Biochemistry I taught by Kimberly Lane at the Radford University, Radford, VA, USA. This reservation includes Sandbox Reserved 1730 through Sandbox Reserved 1749.
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Contents

Structure

Primary Structure: ~461 amino acids

Secondary Structure: 12 alpha helicies, 12 beta strands

Tertiary Structure: N-Terminal Regulatory Domain, C-Terminal Catalytic Domain

Quaternary Structure: Forms a homodimer

Function

Glucose binds to hexokinase, which is then attacked by ATP. The terminal phosphate group on the ATP binds to the glucose, creating two products: glucose-6-phosphate, and ADP. Hexokinase serves as a catalyst for this reaction.

Disease

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Structural highlights

This is a sample scene created with SAT to by Group, and another to make of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

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References

1. D. J. Roberts, S. Miyamoto. Hexokinase II integrates energy metabolism and cellular protection: Akting on mitochondria and TORCing to autophagy. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4291497/ (Accessed 10/21/2022).

2. Anne M. Mulichuk, John E. Wilson, Kaillathe Padmanabhan, Michael Garavito. The structure of mammalian hexokinase-1. https://www.nature.com/articles/nsb0798_555. (Accessed 10/21/2022).

3. Valerie P. Tan, Shigeki Miyamoto. HK2/hexokinase-II integrates glycolysis and autophagy to confer cellular protection. https://pubmed.ncbi.nlm.nih.gov/26075878/. (Accessed 10/21/2022).

4. M. Magnani, M. Bianchi, A. Casabianca, V. Stocchi, A. Daniele, F. Altruda, M. Ferrone, L. Silengo. A recombinant human 'mini'-hexokinase is catalytically active and regulated by hexose 6-phosphates. https://pubmed.ncbi.nlm.nih.gov/1637300/. (Accessed 10/21/2022).

5. A. E. Aleshin, C. Zeng, G. P. Bourenkov, H. D. Bartunik, H. J. Fromm, R. B. Honzatko. The mechanism of regulation of hexokinase: new insights from the crystal structure of recombinant human brain hexokinase complexed with glucose and glucose-6-phosphate. https://pubmed.ncbi.nlm.nih.gov/9493266/. (Accessed 10/21/2022).

6. Richard Southworth, Katherine A. B. Davey, Alice Warley, Pamela B. Garlick. A reevaluation of the roles of hexokinase I and II in the heart. https://journals.physiology.org/doi/full/10.1152/ajpheart.00664.2006. (Accessed 10/21/2022)

7. Èric Claeyssen, Jean Rivoal. Isozymes of plant hexokinase: Occurrence, properties and functions. https://www.sciencedirect.com/science/article/abs/pii/S0031942206007606. (Accessed 10/21/2022)


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