7yz7

Structural highlights

Function

FOXH1_DANRE Transcriptional activator. Activates an activin response element (ARE). Recognizes and binds to the DNA sequence 5'-TGT[GT][GT]ATT-3'. Modulator of nodal signaling required for organizer formation. Also required for the development of dorsal axial structures and left-right symmetry.^{[1] [2]}

References

1. ↑ Pogoda HM, Solnica-Krezel L, Driever W, Meyer D. The zebrafish forkhead transcription factor FoxH1/Fast1 is a modulator of nodal signaling required for organizer formation. Curr Biol. 2000 Sep 7;10(17):1041-9. PMID:10996071
2. ↑ Sirotkin HI, Gates MA, Kelly PD, Schier AF, Talbot WS. Fast1 is required for the development of dorsal axial structures in zebrafish. Curr Biol. 2000 Sep 7;10(17):1051-4. doi: 10.1016/s0960-9822(00)00679-5. PMID:10996072 doi:http://dx.doi.org/10.1016/s0960-9822(00)00679-5