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1hla
From Proteopedia
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STRUCTURE OF THE HUMAN CLASS I HISTOCOMPATIBILITY ANTIGEN, HLA-A2
Contents |
Overview
The class I histocompatibility antigen from human cell membranes has two, structural motifs: the membrane-proximal end of the glycoprotein contains, two domains with immunoglobulin-folds that are paired in a novel manner, and the region distal from the membrane is a platform of eight, antiparallel beta-strands topped by alpha-helices. A large groove between, the alpha-helices provides a binding site for processed foreign antigens., An unknown 'antigen' is found in this site in crystals of purified HLA-A2.
Disease
Known diseases associated with this structure: Abacavir hypersensitivity, susceptibility to OMIM:[142800], Ankylosing spondylitis, susceptibility to, 1 OMIM:[142800], Hypoproteinemia, hypercatabolic OMIM:[109700], Stevens-Johnson syndrome, susceptibility to OMIM:[142800]
About this Structure
1HLA is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structure of the human class I histocompatibility antigen, HLA-A2., Bjorkman PJ, Saper MA, Samraoui B, Bennett WS, Strominger JL, Wiley DC, Nature. 1987 Oct 8-14;329(6139):506-12. PMID:3309677
Page seeded by OCA on Mon Nov 12 17:19:42 2007
