The glyoxylate cycle, a variation of the tricarboxylic acid cycle, is an anabolic pathway occurring in plants, bacteria, protists, and fungi. The glyoxylate cycle centers on the conversion of acetyl-CoA to succinate for the synthesis of carbohydrates.
The glyoxylate cycle uses six of the eight enzymes associated with the tricarboxylic acid cycle: citrate synthase, aconitase, succinate dehydrogenase, fumarase, and malate dehydrogenase.
1) Citrate Synthase
4C to a 6C molecule
2) Aconitase
6C Citrate => 6C
6C cis-Aconitate => 6C
3) Succinate Dehydrogenase
=>
The two cycles differ in that in the glyoxylate cycle, isocitrate is converted into and succinate by isocitrate lyase (ICL) instead of into α-ketoglutarate.
. The ternary complex contains malate, acetyl-CoA and Mg+2 ion[1].
