1hu3

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Image:1hu3.gif

1hu3, resolution 2.37Å

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MIDDLE DOMAIN OF HUMAN EIF4GII

Overview

The X-ray structure of the phylogenetically conserved middle portion of, human eukaryotic initiation factor (eIF) 4GII has been determined at 2.4 A, resolution, revealing a crescent-shaped domain consisting of ten alpha, helices arranged as five HEAT repeats. Together with the ATP-dependent RNA, helicase eIF4A, this HEAT domain suffices for 48S ribosomal complex, formation with a picornaviral RNA internal ribosome entry site (IRES)., Structure-based site-directed mutagenesis was used to identify two, adjacent features on the surface of this essential component of the, translation initiation machinery that, respectively, bind eIF4A and a, picornaviral IRES. The structural and biochemical results provide, mechanistic insights into both cap-dependent and cap-independent, translation initiation.

About this Structure

1HU3 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

A conserved HEAT domain within eIF4G directs assembly of the translation initiation machinery., Marcotrigiano J, Lomakin IB, Sonenberg N, Pestova TV, Hellen CU, Burley SK, Mol Cell. 2001 Jan;7(1):193-203. PMID:11172724

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