Structural highlights
Function
A0A060BFD5_9ENTO
Publication Abstract from PubMed
Echovirus 3 (E3), a serotype of human enterovirus B (HEV-B), causes severe diseases in infants. Here, we determined the structures of E3 with a monoclonal antibody (MAb) 6D10 by cryo-EM to comprehensively understand the specificities and the immunological characteristic of this serotype. The solved cryo-EM structures of the F-, A-, and E-particles of E3 bound with 6D10 revealed the structural features of the virus-antibody interface. Importantly, the structures of E-particles bound with 6D10 revealed for the first time the nature of the C-terminus of VP1 for HEV-Bs at the structural level. The highly immunogenic nature of this region in the E-particles provides new strategies for vaccine development for HEV-Bs.
Structural Basis for the Immunogenicity of the C-Terminus of VP1 of Echovirus 3 Revealed by the Binding of a Neutralizing Antibody.,Qi S, Fu W, Fan J, Zhang L, Zheng B, Wang K, Wang X, Zhu L, Li X, Zhang Y Viruses. 2022 Oct 22;14(11):2322. doi: 10.3390/v14112322. PMID:36366420[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Qi S, Fu W, Fan J, Zhang L, Zheng B, Wang K, Wang X, Zhu L, Li X, Zhang Y. Structural Basis for the Immunogenicity of the C-Terminus of VP1 of Echovirus 3 Revealed by the Binding of a Neutralizing Antibody. Viruses. 2022 Oct 22;14(11):2322. doi: 10.3390/v14112322. PMID:36366420 doi:http://dx.doi.org/10.3390/v14112322
