Structural highlights
Function
BAIB_CLOSV Functions in the bile acid 7alpha-dehydroxylation pathway, which forms secondary bile acids via the 7alpha-dehydroxylation of primary bile acids, and is carried out by intestinal anaerobic bacteria. Catalyzes the initial step in this pathway, i.e. the ATP-dependent thioesterification of primary bile acids with coenzyme A. Is active with C-24 bile acids with free carboxyl groups such as cholate, deoxycholate and chenodeoxycholate. Produces AMP and pyrophosphate in addition to the bile acid-CoA thioester.[1]
References
- ↑ Mallonee DH, Adams JL, Hylemon PB. The bile acid-inducible baiB gene from Eubacterium sp. strain VPI 12708 encodes a bile acid-coenzyme A ligase. J Bacteriol. 1992 Apr;174(7):2065-71. doi: 10.1128/jb.174.7.2065-2071.1992. PMID:1551828 doi:http://dx.doi.org/10.1128/jb.174.7.2065-2071.1992
