1jk8
From Proteopedia
Crystal structure of a human insulin peptide-HLA-DQ8 complex
Overview
The class II major histocompatibility complex (MHC) glycoproteins HLA-DQ8 and HLA-DQ2 in humans and I-A(g7) in nonobese diabetic (NOD) mice are the major risk factors for increased susceptibility to type 1 diabetes. Using X-ray crystallography, we have determined the three-dimensional structure of DQ8 complexed with an immunodominant peptide from insulin. The similarity of the DQ8, DQ2 and I-A(g7) peptide-binding pockets suggests that diabetes is caused by the same antigen-presentation event(s) in humans and NOD mice. Correlating type 1 diabetes epidemiology and MHC sequences with the DQ8 structure suggests that other structural features of the P9 pocket in addition to position 57 contribute to susceptibility to type 1 diabetes.
About this Structure
1JK8 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structure of a human insulin peptide-HLA-DQ8 complex and susceptibility to type 1 diabetes., Lee KH, Wucherpfennig KW, Wiley DC, Nat Immunol. 2001 Jun;2(6):501-7. PMID:11376336 Page seeded by OCA on Fri May 2 21:19:24 2008
