Structural highlights
Disease
NFIX_HUMAN 19p13.3 microduplication syndrome;Malan overgrowth syndrome;Marshall-Smith syndrome. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry.
Function
NFIX_HUMAN Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.
