1ice
From Proteopedia
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STRUCTURE AND MECHANISM OF INTERLEUKIN-1BETA CONVERTING ENZYME
Overview
Interleukin-1 beta converting enzyme (ICE) processes an inactive precursor, to the proinflammatory cytokine, interleukin-1 beta, and may regulate, programmed cell death in neuronal cells. The high-resolution structure of, human ICE in complex with an inhibitor has been determined by X-ray, diffraction. The structure confirms the relationship between human ICE and, cell-death proteins in other organisms. The active site spans both the 10, and 20K subunits, which associate to form a tetramer, suggesting a, mechanism for ICE autoactivation.
About this Structure
1ICE is a Single protein structure of sequence from [1] with ACE as ligand. The following page contains interesting information on the relation of 1ICE with [Caspases]. Active as Caspase-1, with EC number 3.4.22.36 Full crystallographic information is available from OCA.
Reference
Structure and mechanism of interleukin-1 beta converting enzyme., Wilson KP, Black JA, Thomson JA, Kim EE, Griffith JP, Navia MA, Murcko MA, Chambers SP, Aldape RA, Raybuck SA, et al., Nature. 1994 Jul 28;370(6487):270-5. PMID:8035875
Page seeded by OCA on Mon Nov 12 17:28:43 2007
Categories: Caspase-1 | Caspases | Single protein | Griffith, J.P. | Kim, E.E. | Navia, M.A. | Wilson, K.P. | ACE | Cytokine
