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1ik0
From Proteopedia
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Solution Structure of Human IL-13
Contents |
Overview
Interleukin-13 has been implicated as a key factor in asthma, allergy, atopy and inflammatory response, establishing the protein as a valuable, therapeutic target. The high-resolution solution structure of human IL-13, has been determined by multidimensional NMR. The resulting structure is, consistent with previous short-chain left-handed four-helix bundles, where, a significant similarity in the folding topology between IL-13 and IL-4, was observed. IL-13 shares a significant overlap in biological function, with IL-4, a result of the common alpha chain component (IL-4Ralpha) in, their respective receptors. Based on the available structural and, mutational data, an IL-13/IL-4Ralpha model and a sequential mechanism for, forming the signaling heterodimer is proposed for IL-13.
Disease
Known diseases associated with this structure: Allergic rhinitis, susceptibility to OMIM:[147683], Asthma, susceptibility to OMIM:[147683]
About this Structure
1IK0 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Solution structure of human IL-13 and implication for receptor binding., Moy FJ, Diblasio E, Wilhelm J, Powers R, J Mol Biol. 2001 Jun 29;310(1):219-30. PMID:11419948
Page seeded by OCA on Mon Nov 12 17:30:46 2007
