Structural highlights
Function
NAA25_YEAST Non-catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes acetylation of the amino-terminal methionine residues of all proteins beginning with Met-Asp or Met-Glu and of some proteins beginning with Met-Asn or Met-Met. NatB acetylates TPM1 protein and regulates tropomyocin-actin interactions. MDM20 is required for mitochondrial inheritance during budding and together with TPM1, is essential for the integrity and assembly of actin cables. Genetically interacts with CIN8.[1] [2] [3]
References
- ↑ Polevoda B, Cardillo TS, Doyle TC, Bedi GS, Sherman F. Nat3p and Mdm20p are required for function of yeast NatB Nalpha-terminal acetyltransferase and of actin and tropomyosin. J Biol Chem. 2003 Aug 15;278(33):30686-97. PMID:12783868 doi:10.1074/jbc.M304690200
- ↑ Singer JM, Shaw JM. Mdm20 protein functions with Nat3 protein to acetylate Tpm1 protein and regulate tropomyosin-actin interactions in budding yeast. Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7644-9. PMID:12808144 doi:10.1073/pnas.1232343100
- ↑ Hermann GJ, King EJ, Shaw JM. The yeast gene, MDM20, is necessary for mitochondrial inheritance and organization of the actin cytoskeleton. J Cell Biol. 1997 Apr 7;137(1):141-53. PMID:9105043 doi:10.1083/jcb.137.1.141
