Structural highlights
Function
KBP_ECOLI Highly specific potassium binding protein that is required for normal growth in the presence of high levels of external K(+). May act as a sensor of cytoplasmic K(+) concentration. Binds a single K(+) ion, which induces a large conformational change. Can also bind the larger alkali metal ions Rb(+) and Cs(+), and NH(4)(+) (PubMed:27112601). May be involved in the regulation of peptidoglycan cross-linking (PubMed:25422305).[1] [2] GFP_AEQVI Energy-transfer acceptor. Its role is to transduce the blue chemiluminescence of the protein aequorin into green fluorescent light by energy transfer. Fluoresces in vivo upon receiving energy from the Ca(2+)-activated photoprotein aequorin.
References
- ↑ Bernal-Cabas M, Ayala JA, Raivio TL. The Cpx envelope stress response modifies peptidoglycan cross-linking via the L,D-transpeptidase LdtD and the novel protein YgaU. J Bacteriol. 2015 Feb;197(3):603-14. doi: 10.1128/JB.02449-14. Epub 2014 Nov 24. PMID:25422305 doi:http://dx.doi.org/10.1128/JB.02449-14
- ↑ Ashraf KU, Josts I, Mosbahi K, Kelly SM, Byron O, Smith BO, Walker D. The Potassium Binding Protein Kbp Is a Cytoplasmic Potassium Sensor. Structure. 2016 May 3;24(5):741-9. doi: 10.1016/j.str.2016.03.017. Epub 2016 Apr , 21. PMID:27112601 doi:http://dx.doi.org/10.1016/j.str.2016.03.017
